Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila

Abstract

The patterning of sensory bristles on the dorsal thorax of flies is regulated by two transcription factor families but the dynamics of this regulation is unclear. Here, the authors visualize seven E(spl)-HLH proteins, showing their regulated expression promotes mutual inhibition by Notch during notum patterning.