Indian Journal of Ophthalmology (Jan 2024)

Natural course of non-center-involving diabetic macular edema progression in patients under initial observation

  • Divya Pradhana,
  • N Swathi Priya,
  • George J Manayath,
  • Sucheta Kulkarni,
  • Umesh C Behera,
  • Tushar Agarwal,
  • Manisha Agarwal,
  • Shalin Shah,
  • A Giridhar,
  • Janani Surya,
  • Kim Ramasamy,
  • T P Vignesh,
  • Sivaprasad Shoba,
  • Muna Bhende,
  • Rajiv Raman

DOI
https://doi.org/10.4103/IJO.IJO_2182_22
Journal volume & issue
Vol. 72, no. 2
pp. 236 – 239

Abstract

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Purpose: We aim to report the natural course of non-center involving diabetic macular edema (NCIDME) progression to center involving diabetic macular edema (CIDME) and associated risk factors. Methods: This is a multicenter retrospective comparative study. Data was collected from electronic medical records from 8 centers in India covering. We included patients with type 2 diabetes above 18 years of age with treatment-naïve NCIDME on OCT and best-corrected visual acuity at baseline of 6/12 or better who were under observation for NCIDME and had 2 years follow-up data. Results: Out of 72 patients with NCIDME, 26.38% patients progressed to CI DME by 2 years, and the visit wise proportion was 11.11% at 6 months, 7% at 1st year and 8.3% at 2 years. The change in CST was statistically significant at 2 years in patients who developed CIDME, the mean difference was 137.73 ± 48.56 microns p = 0.045. Duration of diabetes mellitus > 10 years was the only risk factor for conversion to CIDME. Conclusion: A quarter of eyes with NCIDME developed CIDME and 15% progressed from NPDR to PDR by 2 years, highlighting the disease burden in these patients with NCIDME.

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