Nature Communications (Aug 2019)

Brain-targeted drug delivery by manipulating protein corona functions

  • Zui Zhang,
  • Juan Guan,
  • Zhuxuan Jiang,
  • Yang Yang,
  • Jican Liu,
  • Wei Hua,
  • Ying Mao,
  • Cheng Li,
  • Weiyue Lu,
  • Jun Qian,
  • Changyou Zhan

DOI
https://doi.org/10.1038/s41467-019-11593-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Plasma proteins may severely affect the in vivo performance of liposomes. Here, the authors develop bio-inspired liposomes that specifically absorb brain-targeted apolipoproteins and preserve their bioactivities, thereby achieving efficient brain targeting with minor influence on immunocompatibility of liposomes.