A computational model of neurodegeneration in Alzheimer’s disease

D. Jones; V. Lowe; J. Graff-Radford; H. Botha; L. Barnard; D. Wiepert; M. C. Murphy; M. Murray; M. Senjem; J. Gunter; H. Wiste; B. Boeve; D. Knopman; R. Petersen; C. Jack

doi:10.1038/s41467-022-29047-4

Nature Communications (Mar 2022)

A computational model of neurodegeneration in Alzheimer’s disease

D. Jones,
V. Lowe,
J. Graff-Radford,
H. Botha,
L. Barnard,
D. Wiepert,
M. C. Murphy,
M. Murray,
M. Senjem,
J. Gunter,
H. Wiste,
B. Boeve,
D. Knopman,
R. Petersen,
C. Jack

Affiliations

D. Jones: Department of Neurology, Mayo Clinic
V. Lowe: Department of Radiology, Mayo Clinic
J. Graff-Radford: Department of Neurology, Mayo Clinic
H. Botha: Department of Neurology, Mayo Clinic
L. Barnard: Department of Neurology, Mayo Clinic
D. Wiepert: Department of Neurology, Mayo Clinic
M. C. Murphy: Department of Radiology, Mayo Clinic
M. Murray: Department of Neuroscience, Mayo Clinic
M. Senjem: Department of Information Technology, Mayo Clinic
J. Gunter: Department of Information Technology, Mayo Clinic
H. Wiste: Department of Health Sciences Research, Mayo Clinic
B. Boeve: Department of Neurology, Mayo Clinic
D. Knopman: Department of Neurology, Mayo Clinic
R. Petersen: Department of Neurology, Mayo Clinic
C. Jack: Department of Radiology, Mayo Clinic

DOI: https://doi.org/10.1038/s41467-022-29047-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

Read online

Low-dimensional representations of functional brain anatomy relevant for dementia syndromes may exist. Here the authors propose a computational model of mental functions to catalogue this anatomy in Alzheimer’s and related dementias.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal