Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception

• Samuel J. Pellock,
• Benjamin C. Creekmore,
• William G. Walton,
• Naimee Mehta,
• Kristen A. Biernat,
• Andrew P. Cesmat,
• Yamuna Ariyarathna,
• Zachary D. Dunn,
• Bo Li,
• Jian Jin,
• Lindsey I. James,
• Matthew R. Redinbo

Affiliations

Samuel J. Pellock

†Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Benjamin C. Creekmore

†Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

William G. Walton

†Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Naimee Mehta

‡Center for Integrated Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Kristen A. Biernat

†Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Andrew P. Cesmat

†Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Yamuna Ariyarathna

‡Center for Integrated Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Zachary D. Dunn

†Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Bo Li

†Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Jian Jin

Department of Pharmacological Sciences, Icahn School of Medicine at Mt. Sinai, New York, New York, United States

Lindsey I. James

‡Center for Integrated Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Matthew R. Redinbo

†Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States