JCRPE (Dec 2019)

A Case of Autosomal Dominant Osteopetrosis Type 2 with a CLCN7 Gene Mutation

  • Sol Kang,
  • Young Kyung Kang,
  • Jun Ah Lee,
  • Dong Ho Kim,
  • Jung Sub Lim

DOI
https://doi.org/10.4274/jcrpe.galenos.2019.2018.0229
Journal volume & issue
Vol. 11, no. 4
pp. 439 – 443

Abstract

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Osteopetrosis is a rare genetic disease characterized by increased bone density and bone fractures due to defective osteoclast function. Autosomal dominant osteopetrosis type 2 (ADO-2), Albers-Schonberg disease, is characterized by the sclerosis of bones, predominantly involving the spine, pelvis and the base of the skull. Here, we report a typical case of osteopetrosis in a 17.7-year-old male who carries a heterozygous c.746C>T mutation in exon 9 in the chloride voltage-gated channel 7 (CLCN7) gene. The patient’s spine showed multiple sclerotic changes including sandwich vertebra. His father had the same mutation but his skeletal radiographs were normal. This is the first reported case of ADO-2, confirmed by genetic testing in a Korean patient.

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