植物甾醇在脂质体中的作用研究进展Progress on the effect of phytosterols in liposomes

Abstract

脂质体具有双亲性、靶向性、可控性、保护性等优良性质,但普通脂质体所含的胆固醇易引起高脂血症、动脉粥样硬化等病症，从而导致其在应用方面受到极大的限制。将植物甾醇替代胆固醇添加到脂质体中可降低血液中胆固醇浓度，调节脂质体的通透性、稳定性等性质。综述了植物甾醇对脂质体的作用及国内外含植物甾醇的脂质体在包埋脂类、抗氧化剂、维生素、多肽、蛋白质等方面的研究，以期为植物甾醇添加到脂质体中的研究提供思路和依据。 Liposomes have excellent properties such as amphiphilicity, targeting, controllability and protection. However, the cholesterol contained in common liposomes is prone to cause hyperlipidemia, atherosclerosis and other diseases, which leads to great limitations in its application. The addition of phytosterols to liposomes as a substitute for cholesterol can reduce the concentration of cholesterol in blood and regulate the permeability, stability and other properties of liposomes. The effects of phytosterols on liposomes and the research progress on encapsulating lipids, antioxidants, vitamins, peptides and proteins in liposomes containing phytosterols at home and abroad were reviewed so as to provide ideas and basis for phytosterol added to liposomes.

Keywords

• 脂质体；磷脂；植物甾醇；胆固醇
• liposome; phospholipid; phytosterol; cholesterol