Subungual melanoma - what you need to know about it. A literature review

Abstract

Introduction and objective: Melanoma is one of the most malignant skin cancers originating from pigment cells, accounting for 5–7% of all skin cancers. The prognosis, especially in case of late diagnosis, is poor. The aim of the study is to systematise information on subungual melanoma. To raise awareness among the public and professionals working in the skin care sector of the diagnosis, early detection and treatment of subungual melanoma. Brief description of the state of knowledge: Subungual melanoma originates from subungual melanoma lentigines and constitutes from 0.7% to 3.5% of all malignant melanomas. Among dark-skinned populations, this subtype accounts for up to 30% and is the most common subtype of malignant melanoma among African Americans, Asians, and Latinos. Subungual melanoma occurs asymmetrically, most often affecting the big toe or thumb. In this disease, the starting point are melanocytes, which undergo malignant transformation within the nail matrix. A symptom of the disease may be melanonychia, a streak of pigment or irregular discoloration, eventually it takes the form of a triangle. This symptom indicates an advanced stage of the disease. The basis for making the diagnosis is dermoscopy and biopsy. Grazzini et al. suggest conducting a biopsy in each case where one nail plate is affected and the lesion persists for more than 6 months. An important element of diagnostics that helps diagnose of subungual melanoma is the ABCDEF algorithm. Knowledge of the above-mentioned helps to detect disturbing symptoms at an early stage of the disease, which improves the prognosis and increases the chances of cure. Summary: Early detection of melanoma gives a better chance of cure, reduces mortality and complications of the disease, therefore any action to increase public knowledge and awareness on the subject is important.

Keywords

• melanoma
• subungual melanoma
• melanocytic lesion
• dermoscopy