Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis

Abstract

The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis. Four peptides with biological activities were synthesized through SPPS and the bioactive cyclic heptapeptide pseudostellarin D was obtained via solution-phase peptide synthesis. It is worth noting that FPID can be readily regenerated after the peptide coupling reaction.

Keywords

• cyclic peptide
• FPID
• hypervalent iodine(III) reagent
• recyclable
• solid-phase peptide synthesis (SPPS)