Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar

Abstract

Ventricular arrhythmias after heart attack are a leading cause of death. Here the authors show, in a porcine model, that KCNE3 and KCNE4 upregulation and a unique pattern of repolarization heterogeneity in the scar facilitate reentrant ventricular tachycardia.