Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

Seung Wook Yang; Xin Huang; Wenwei Lin; Jaeki Min; Darcie J. Miller; Anand Mayasundari; Patrick Rodrigues; Elizabeth C. Griffith; Clifford T. Gee; Lei Li; Wei Li; Richard E. Lee; Zoran Rankovic; Taosheng Chen; Patrick Ryan Potts

doi:10.1038/s41467-020-18708-x

Nature Communications (Oct 2020)

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

Seung Wook Yang,
Xin Huang,
Wenwei Lin,
Jaeki Min,
Darcie J. Miller,
Anand Mayasundari,
Patrick Rodrigues,
Elizabeth C. Griffith,
Clifford T. Gee,
Lei Li,
Wei Li,
Richard E. Lee,
Zoran Rankovic,
Taosheng Chen,
Patrick Ryan Potts

Affiliations

Seung Wook Yang: Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital
Xin Huang: Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital
Wenwei Lin: Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital
Jaeki Min: Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital
Darcie J. Miller: Department of Structural Biology, St. Jude Children’s Research Hospital
Anand Mayasundari: Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital
Patrick Rodrigues: Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children’s Research Hospital
Elizabeth C. Griffith: Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital
Clifford T. Gee: Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital
Lei Li: Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California Irvine
Wei Li: Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California Irvine
Richard E. Lee: Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital
Zoran Rankovic: Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital
Taosheng Chen: Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital
Patrick Ryan Potts: Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital

DOI: https://doi.org/10.1038/s41467-020-18708-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Testis-restricted melanoma antigen (MAGE) proteins function as substrate adapters for E3 ubiquitin ligases. Biochemical and structural analyses of MAGE-A11 provide insight into the substrate binding mode of MAGE proteins and enable discovery of potent, cytotoxic inhibitors of MAGE-A11:substrate interaction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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