Nature Communications (Jan 2018)
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology
- Alec J. Hirsch,
- Victoria H. J. Roberts,
- Peta L. Grigsby,
- Nicole Haese,
- Matthias C. Schabel,
- Xiaojie Wang,
- Jamie O. Lo,
- Zheng Liu,
- Christopher D. Kroenke,
- Jessica L. Smith,
- Meredith Kelleher,
- Rebecca Broeckel,
- Craig N. Kreklywich,
- Christopher J. Parkins,
- Michael Denton,
- Patricia Smith,
- Victor DeFilippis,
- William Messer,
- Jay A. Nelson,
- Jon D. Hennebold,
- Marjorie Grafe,
- Lois Colgin,
- Anne Lewis,
- Rebecca Ducore,
- Tonya Swanson,
- Alfred W. Legasse,
- Michael K. Axthelm,
- Rhonda MacAllister,
- Ashlee V. Moses,
- Terry K. Morgan,
- Antonio E. Frias,
- Daniel N. Streblow
Affiliations
- Alec J. Hirsch
- The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)
- Victoria H. J. Roberts
- Division of Reproductive & Developmental Sciences, ONPRC
- Peta L. Grigsby
- Division of Reproductive & Developmental Sciences, ONPRC
- Nicole Haese
- The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)
- Matthias C. Schabel
- Advanced Imaging Research Center, OHSU
- Xiaojie Wang
- Advanced Imaging Research Center, OHSU
- Jamie O. Lo
- Department of Obstetrics & Gynecology, OHSU
- Zheng Liu
- Advanced Imaging Research Center, OHSU
- Christopher D. Kroenke
- Advanced Imaging Research Center, OHSU
- Jessica L. Smith
- The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)
- Meredith Kelleher
- Division of Reproductive & Developmental Sciences, ONPRC
- Rebecca Broeckel
- The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)
- Craig N. Kreklywich
- The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)
- Christopher J. Parkins
- The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)
- Michael Denton
- The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)
- Patricia Smith
- The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)
- Victor DeFilippis
- The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)
- William Messer
- Department of Molecular Microbiology & Immunology, OHSU
- Jay A. Nelson
- The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)
- Jon D. Hennebold
- Division of Reproductive & Developmental Sciences, ONPRC
- Marjorie Grafe
- Neuropathology, OHSU
- Lois Colgin
- Pathology Services Unit, Division of Comparative Medicine, ONPRC
- Anne Lewis
- Pathology Services Unit, Division of Comparative Medicine, ONPRC
- Rebecca Ducore
- Pathology Services Unit, Division of Comparative Medicine, ONPRC
- Tonya Swanson
- Division of Pathobiology & Immunology, Oregon National Primate Research Center (ONPRC)
- Alfred W. Legasse
- Division of Pathobiology & Immunology, Oregon National Primate Research Center (ONPRC)
- Michael K. Axthelm
- Division of Pathobiology & Immunology, Oregon National Primate Research Center (ONPRC)
- Rhonda MacAllister
- Clinical Services Unit, Division of Comparative Medicine, ONPRC
- Ashlee V. Moses
- The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)
- Terry K. Morgan
- Department of Obstetrics & Gynecology, OHSU
- Antonio E. Frias
- Division of Reproductive & Developmental Sciences, ONPRC
- Daniel N. Streblow
- The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)
- DOI
- https://doi.org/10.1038/s41467-017-02499-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Zika virus infection during pregnancy can result in birth defects, but underlying pathogenesis at the maternal-fetal interface is unclear. Here, the authors use non-invasive in vivo imaging of Zika-infected rhesus macaques and show that infection results in abnormal oxygen transport across the placenta.
