Nature Communications (Jan 2021)
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain
- Anoushka Joglekar,
- Andrey Prjibelski,
- Ahmed Mahfouz,
- Paul Collier,
- Susan Lin,
- Anna Katharina Schlusche,
- Jordan Marrocco,
- Stephen R. Williams,
- Bettina Haase,
- Ashley Hayes,
- Jennifer G. Chew,
- Neil I. Weisenfeld,
- Man Ying Wong,
- Alexander N. Stein,
- Simon A. Hardwick,
- Toby Hunt,
- Qi Wang,
- Christoph Dieterich,
- Zachary Bent,
- Olivier Fedrigo,
- Steven A. Sloan,
- Davide Risso,
- Erich D. Jarvis,
- Paul Flicek,
- Wenjie Luo,
- Geoffrey S. Pitt,
- Adam Frankish,
- August B. Smit,
- M. Elizabeth Ross,
- Hagen U. Tilgner
Affiliations
- Anoushka Joglekar
- Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine
- Andrey Prjibelski
- Center for Algorithmic Biotechnology, Institute of Translational Biomedicine, St. Petersburg State University
- Ahmed Mahfouz
- Department of Human Genetics, Leiden University Medical Center
- Paul Collier
- Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine
- Susan Lin
- Graduate Program in Neuroscience, Weill Cornell Medical College
- Anna Katharina Schlusche
- Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine
- Jordan Marrocco
- Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University
- Stephen R. Williams
- 10x Genomics
- Bettina Haase
- The Vertebrate Genomes Lab, The Rockefeller University
- Ashley Hayes
- 10x Genomics
- Jennifer G. Chew
- 10x Genomics
- Neil I. Weisenfeld
- 10x Genomics
- Man Ying Wong
- Brain and Mind Research Institute and Appel Alzheimer’s Research Institute, Weill Cornell Medicine
- Alexander N. Stein
- School of General Studies, Columbia University
- Simon A. Hardwick
- Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine
- Toby Hunt
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Qi Wang
- Section of Bioinformatics and Systems Cardiology, University Hospital
- Christoph Dieterich
- Section of Bioinformatics and Systems Cardiology, University Hospital
- Zachary Bent
- 10x Genomics
- Olivier Fedrigo
- The Vertebrate Genomes Lab, The Rockefeller University
- Steven A. Sloan
- Department of Human Genetics, Emory University School of Medicine
- Davide Risso
- Department of Statistical Sciences, University of Padova
- Erich D. Jarvis
- The Vertebrate Genomes Lab, The Rockefeller University
- Paul Flicek
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Wenjie Luo
- Brain and Mind Research Institute and Appel Alzheimer’s Research Institute, Weill Cornell Medicine
- Geoffrey S. Pitt
- Graduate Program in Neuroscience, Weill Cornell Medical College
- Adam Frankish
- European Molecular Biology Laboratory, European Bioinformatics Institute
- August B. Smit
- Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University
- M. Elizabeth Ross
- Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine
- Hagen U. Tilgner
- Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine
- DOI
- https://doi.org/10.1038/s41467-020-20343-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Alternative RNA splicing varies across the brain. Its mapping at single cell resolution is unclear. Here, the authors provide a spatial and single-cell splicing atlas reporting brain region- and cell type-specific expression of different isoforms in the postnatal mouse brain.
