The effect of phytoextract containing ecdysteroids and flavonoids on the metabolic parameters of pigs and white mice

Abstract

The purpose of the research is to study the effect of extractive substances from a complex of herbs (R. Carthamoides, S. Coronate, F. ulmaria )on individual indicators of the metabolism of laboratory mice, pregnant sows and piglets obtained from them. A phytoextract containing ecdysteroids and flavonoids was orally administered to white mice ( three experimental and one control group of 15 mice) in doses of 0.1; 0.2 and 0.3 ml during 14 days that provided an increase in the average daily weight gain by 20.8-48.5% (P <0.05) in comparison with the control. The introduction into the diet of pregnant sows (three experimental groups and one control group of 10 sows) of an additive containing a phytoextract once a day at doses 3, 5 and 10 grams per head within 30 days before farrowing did not cause deviations from the norm of the studied biochemical blood parameters (total protein, albumin, cholesterol, calcium, phosphorus, magnesium, urea, creatinine, ALT, AST). The blood parameters of sows in the experimental groups characterizing the metabolic status of the organism were within the reference limits: total protein 60.7±0.4-62.0±0.3 g/l; albumin 44.2±0.4-52.7±1.8 g/l; cholesterol 2.14±0.04-2.90±0.01 mmol/l; Ca 2.50±0.05-2.62±0.01 mmol/l; P 2.91±0.0-3.16±0.04 mmol/l; Mg 0.92±0.02-1.28±0.01 mmol/l; AST 27.6±2.4-29.3±0.5 units; ALT 23.7±1.1-26.9±1.3 units; urea 4.8±0.2-7.9±0.5 mmol/l; creatinine 101.2±3.5-110.0±2.1 mkmol/l. The number of newborn piglets obtained from sows in the experimental groups exceeded the indicator in the control (127 heads) by 6.2%, of which live by 10.6% (in the control, 113 heads), the number transferred for weaning by 11.2% (in control 107 heads), gross growth by 9.8% (control 887 kg). The rest of the studied parameters of piglets (average weight of a piglet during transfer, average daily growth, survivability) did not differ significantly from the control (P> 0.05). It has been established that the phytoextract had an anabolic effect on white mice, did not cause a negative effect on the studied biochemical parameters of metabolism in pregnant sows, and contributed to an increase in the number of live newborns in comparison with the control.

Keywords

• plant extract
• laboratory mice
• sows
• blood biochemistry
• anabolic effect