INITIAL FORMS OF CEREBROVASCULAR INSUFFICIENCY: DIFFERENT APPROACHES TO THERAPY (ON THE RESULTS OF THE CLINICAL AND EPIDEMIOLOGICAL PROGRAM «PROFILE»)

Abstract

The article presents the results of a study of the efficacy and safety of Cavinton Comforte® (vinpocetine) in patients with initial manifestations of chronic cerebrovascular disease (CСD) in outpatient neurological and therapeutic practice. 4,410 patients with a verified diagnosis of stage I - II discirculatory encephalopathy were enrolled to the program. The study showed high efficacy of therapy with Cavinton Comforte® in terms of both subjective characteristics and neuropsychological tests data. Positive changes in neuropsycological test results, as in patient complaints, were already evident after one month of treatment. The positive trend persisted with continued therapy up to 3 months. More than 90% of doctors and patients evaluated the efficacy and tolerability of treatment as good and excellent. The study proved the expediency of using the drug in patients with early stages of the chronic CCD. A comparative placebo-controlled study is advisable to further study the efficacy of Cavinton Comfort in patients with chronic cerebral ischemia.

Keywords

• chronic cerebral ischemia
• cerebrovascular diseases
• dyscirculatory encephalopathy
• vinpocetine
• cavinton