Nature Communications (Oct 2021)
CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice
- D. Halperin,
- A. Stavsky,
- R. Kadir,
- M. Drabkin,
- O. Wormser,
- Y. Yogev,
- V. Dolgin,
- R. Proskorovski-Ohayon,
- Y. Perez,
- H. Nudelman,
- O. Stoler,
- B. Rotblat,
- T. Lifschytz,
- A. Lotan,
- G. Meiri,
- D. Gitler,
- O. S. Birk
Affiliations
- D. Halperin
- The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben-Gurion University of the Negev
- A. Stavsky
- Department of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev
- R. Kadir
- The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben-Gurion University of the Negev
- M. Drabkin
- The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben-Gurion University of the Negev
- O. Wormser
- The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben-Gurion University of the Negev
- Y. Yogev
- The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben-Gurion University of the Negev
- V. Dolgin
- The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben-Gurion University of the Negev
- R. Proskorovski-Ohayon
- The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben-Gurion University of the Negev
- Y. Perez
- The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben-Gurion University of the Negev
- H. Nudelman
- Department of Life Sciences and National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev
- O. Stoler
- Department of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev
- B. Rotblat
- Department of Life Sciences and National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev
- T. Lifschytz
- Biological Psychiatry Laboratory, Hadassah-Hebrew University Medical Center
- A. Lotan
- Biological Psychiatry Laboratory, Hadassah-Hebrew University Medical Center
- G. Meiri
- Pre-School Psychiatry Unit, Soroka University Medical Center
- D. Gitler
- Department of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev
- O. S. Birk
- The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben-Gurion University of the Negev
- DOI
- https://doi.org/10.1038/s41467-021-26426-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Molecular mechanisms of attention-deficit hyperactivity disorder (ADHD) are not fully understood. Here the authors demonstrate a mutation in CDH2, encoding N-cadherin, that is associated with ADHD, and in a mouse model, delineate molecular electrophysiological characteristics associated with this mutation.
