Communications Biology (Aug 2022)
Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release
- Sean Harrington,
- Jessica J. Knox,
- Andrew R. Burns,
- Ken-Loon Choo,
- Aaron Au,
- Megan Kitner,
- Cecile Haeberli,
- Jacob Pyche,
- Cassandra D’Amata,
- Yong-Hyun Kim,
- Jonathan R. Volpatti,
- Maximillano Guiliani,
- Jamie Snider,
- Victoria Wong,
- Bruna M. Palmeira,
- Elizabeth M. Redman,
- Aditya S. Vaidya,
- John S. Gilleard,
- Igor Stagljar,
- Sean R. Cutler,
- Daniel Kulke,
- James J. Dowling,
- Christopher M. Yip,
- Jennifer Keiser,
- Inga Zasada,
- Mark Lautens,
- Peter J. Roy
Affiliations
- Sean Harrington
- Department of Pharmacology and Toxicology, University of Toronto
- Jessica J. Knox
- The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
- Andrew R. Burns
- The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
- Ken-Loon Choo
- The Department of Chemistry, University of Toronto
- Aaron Au
- The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
- Megan Kitner
- USDA-ARS Horticultural Crops Research Laboratory
- Cecile Haeberli
- Department of Medical Parasitology and Infection Biology, Swiss-Tropical and Public Health Institute, (Swiss TPH)
- Jacob Pyche
- Department of Pharmacology and Toxicology, University of Toronto
- Cassandra D’Amata
- The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
- Yong-Hyun Kim
- The Department of Chemistry, University of Toronto
- Jonathan R. Volpatti
- Program in Developmental and Stem Cell Biology, The Hospital for Sick Children
- Maximillano Guiliani
- The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
- Jamie Snider
- The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
- Victoria Wong
- The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
- Bruna M. Palmeira
- Department of Comparative Biology and Experimental Medicine, Host-Parasite Interactions (HPI) Program, Faculty of Veterinary Medicine, University of Calgary
- Elizabeth M. Redman
- Department of Comparative Biology and Experimental Medicine, Host-Parasite Interactions (HPI) Program, Faculty of Veterinary Medicine, University of Calgary
- Aditya S. Vaidya
- Institute for Integrative Genome Biology, University of California
- John S. Gilleard
- Department of Comparative Biology and Experimental Medicine, Host-Parasite Interactions (HPI) Program, Faculty of Veterinary Medicine, University of Calgary
- Igor Stagljar
- The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
- Sean R. Cutler
- Institute for Integrative Genome Biology, University of California
- Daniel Kulke
- Research Parasiticides, Bayer Animal Health GmbH
- James J. Dowling
- Program in Developmental and Stem Cell Biology, The Hospital for Sick Children
- Christopher M. Yip
- The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
- Jennifer Keiser
- Department of Medical Parasitology and Infection Biology, Swiss-Tropical and Public Health Institute, (Swiss TPH)
- Inga Zasada
- USDA-ARS Horticultural Crops Research Laboratory
- Mark Lautens
- The Department of Chemistry, University of Toronto
- Peter J. Roy
- Department of Pharmacology and Toxicology, University of Toronto
- DOI
- https://doi.org/10.1038/s42003-022-03819-6
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 14
Abstract
A C. elegans-based screening approach identifies nementin as a nematode-selective nematicide that can be used synergistically with acetylcholinesterase inhibitors
