Nature Communications (May 2021)
Restoration of energy homeostasis by SIRT6 extends healthy lifespan
- A. Roichman,
- S. Elhanati,
- M. A. Aon,
- I. Abramovich,
- A. Di Francesco,
- Y. Shahar,
- M. Y. Avivi,
- M. Shurgi,
- A. Rubinstein,
- Y. Wiesner,
- A. Shuchami,
- Z. Petrover,
- I. Lebenthal-Loinger,
- O. Yaron,
- A. Lyashkov,
- C. Ubaida-Mohien,
- Y. Kanfi,
- B. Lerrer,
- P. J. Fernández-Marcos,
- M. Serrano,
- E. Gottlieb,
- R. de Cabo,
- H. Y. Cohen
Affiliations
- A. Roichman
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- S. Elhanati
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- M. A. Aon
- Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH
- I. Abramovich
- Technion Integrated Cancer Center, Faculty of Medicine, Technion (Israel Institute of Technology)
- A. Di Francesco
- Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH
- Y. Shahar
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- M. Y. Avivi
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- M. Shurgi
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- A. Rubinstein
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- Y. Wiesner
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- A. Shuchami
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- Z. Petrover
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- I. Lebenthal-Loinger
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- O. Yaron
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- A. Lyashkov
- Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH
- C. Ubaida-Mohien
- Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH
- Y. Kanfi
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- B. Lerrer
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- P. J. Fernández-Marcos
- Metabolic Syndrome Group–BIOPROMET, Madrid Institute for Advanced Studies-IMDEA Food, CEI UAM + CSIC
- M. Serrano
- Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Catalan Institution for Research and Advanced Studies (ICREA)
- E. Gottlieb
- Technion Integrated Cancer Center, Faculty of Medicine, Technion (Israel Institute of Technology)
- R. de Cabo
- Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH
- H. Y. Cohen
- The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- DOI
- https://doi.org/10.1038/s41467-021-23545-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Aging is associated with increased frailty and disrupted energy homeostasis. Here, the authors show that SIRT6 overexpression extends the lifespan of male and female mice and demonstrate that SIRT6 optimizes energy homeostasis in old age, which delays frailty and preserves healthy aging.
