Nature Communications (Aug 2019)
Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
- Shaheed A. Abdulhaqq,
- Melween Martinez,
- Guobin Kang,
- Idia V. Rodriguez,
- Stephanie M. Nichols,
- David Beaumont,
- Jocelin Joseph,
- Livio Azzoni,
- Xiangfan Yin,
- Megan Wise,
- David Weiner,
- Qin Liu,
- Andrea Foulkes,
- Jan Münch,
- Frank Kirchhoff,
- Christos Coutifaris,
- Georgia D. Tomaras,
- Carlos Sariol,
- Preston A. Marx,
- Qingsheng Li,
- Edmundo N. Kraiselburd,
- Luis J. Montaner
Affiliations
- Shaheed A. Abdulhaqq
- The Wistar Institute
- Melween Martinez
- Caribbean Primate Research Center and Animal Resources Center, University of Puerto Rico (UPR)
- Guobin Kang
- School of Biological Sciences University of Nebraska
- Idia V. Rodriguez
- Caribbean Primate Research Center and Animal Resources Center, University of Puerto Rico (UPR)
- Stephanie M. Nichols
- Caribbean Primate Research Center and Animal Resources Center, University of Puerto Rico (UPR)
- David Beaumont
- Duke Human Vaccine Institute and Department of Surgery, Immunology and Molecular Genetics and Microbiology, Duke University
- Jocelin Joseph
- The Wistar Institute
- Livio Azzoni
- The Wistar Institute
- Xiangfan Yin
- The Wistar Institute
- Megan Wise
- The Wistar Institute
- David Weiner
- The Wistar Institute
- Qin Liu
- The Wistar Institute
- Andrea Foulkes
- Mount Holyoke College
- Jan Münch
- Institute of Molecular Virology, Ulm University Medical Center
- Frank Kirchhoff
- Institute of Molecular Virology, Ulm University Medical Center
- Christos Coutifaris
- University of Pennsylvania
- Georgia D. Tomaras
- Duke Human Vaccine Institute and Department of Surgery, Immunology and Molecular Genetics and Microbiology, Duke University
- Carlos Sariol
- Caribbean Primate Research Center and Animal Resources Center, University of Puerto Rico (UPR)
- Preston A. Marx
- Tulane National Primate Research Center, and Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University
- Qingsheng Li
- School of Biological Sciences University of Nebraska
- Edmundo N. Kraiselburd
- Caribbean Primate Research Center and Animal Resources Center, University of Puerto Rico (UPR)
- Luis J. Montaner
- The Wistar Institute
- DOI
- https://doi.org/10.1038/s41467-019-11814-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
High frequency semen exposure has been associated with activation of anti-HIV mechanisms in HIV negative sex workers. Here, Abdulhaqq et al. show that repeated vaginal exposure to semen reduces vaginal infection by SIV in non-human primates, and is associated with lower CCR5 expression in CD4 T-cells and a local type-I interferon response.
