Медицинская иммунология (Aug 2016)

EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA

  • V. V. Lim,
  • V. A. Ivanov,
  • L. N. Sorokina,
  • V. N. Mineev,
  • M. A. Nyoma,
  • V. I. Trofimov

DOI
https://doi.org/10.15789/1563-0625-2016-5-451-458
Journal volume & issue
Vol. 18, no. 5
pp. 451 – 458

Abstract

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Sixty patients with allergic bronchial asthma (ABA) and forty-one, with non-allergic bronchial asthma (NABA), as well as 23 healthy controls were under study. Expression of the SOCS5 mRNA from mononuclear blood cells was analyzed by RT-PCR. In patients with bronchial asthma, (ABA and NABA) we determined a significant increase of mRNA expression levels for a SOCS5 negative transcription regulator in peripheral blood mononuclears, in comparison with control group. Thus, an increase of SOCS5-expression, and of the SOCS3 mRNA expression in patients with BA may be associated with protective anti-inflammatory response.

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