F4-neuroprostanes and F2-dihomo-isoprostanes: biomarkers and bioactive oxylipins

Abstract

Under condition of oxidative stress, free radical-catalyzed peroxidation of docosahexaenoic acid (DHA) and adrenic acid (AdA) generates in vivo neuroprostanes (NeuroPs) and dihomo-isoprostanes (dihomo-IsoPs), among a large number of key products participating in many pathophysiological processes. These non-enzymatic oxygenated metabolites display a wide range of biological actions (especially DHA-metabolites), and some of them are now considered as the most reliable indicators of oxidative stress in neurogenerative, neurodevelopmental or cardiovascular diseases. In this review, we will present an overview regarding neuroprostanes and dihomo-isoprostanes and discuss about their biological interests.

Keywords

• biomarkers
• docosahexaenoic acid
• radical peroxidation
• neuroprostanes
• dihomo-isoprostanes
• bioactive oxylipins
• total synthesis