Taurine reverses neurological and neurovascular deficits in Zucker diabetic fatty rats

Fei Li; Omorodola I. Abatan; Howard Kim; Diana Burnett; Dennis Larkin; Irina G. Obrosova; Martin J. Stevens

Neurobiology of Disease (Jun 2006)

Taurine reverses neurological and neurovascular deficits in Zucker diabetic fatty rats

Fei Li,
Omorodola I. Abatan,
Howard Kim,
Diana Burnett,
Dennis Larkin,
Irina G. Obrosova,
Martin J. Stevens

Affiliations

Fei Li: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Omorodola I. Abatan: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Howard Kim: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Diana Burnett: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Dennis Larkin: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Irina G. Obrosova: Pennington, Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70803, USA
Martin J. Stevens: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Division of Medical Sciences, The Medical School, The University of Birmingham, Edgbaston, Birmingham, UK; Corresponding author. Division of Medical Sciences, The Medical School, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Fax: +44 121 414 6919.

Journal volume & issue: Vol. 22, no. 3
pp. 669 – 676

Abstract

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Increased oxidative stress is implicated in the pathogenesis of diabetic peripheral neuropathy (DPN). However, the efficacy of antioxidant therapy on DPN complicating type 2 diabetes remains unexplored. We therefore determined the ability of the antioxidant taurine to reverse deficits of hind limb sciatic motor and digital sensory nerve conduction velocity (NCV), nerve blood flow (NBF), and sensory thresholds in hyperglycemic Zucker diabetic fatty (ZDF) rats. Experimental groups comprised lean nondiabetic (ND), ND treated with taurine (ND + T), untreated ZDF diabetic (D), and D rats treated with taurine (D + T). Compared to ND rats, 23%, 15% and 56% deficits of motor NCV, sensory NCV and NBF, respectively as well as thermal and mechanical hyperalgesia were reversed by taurine. An 84% deficit of dorsal root ganglion neuron calcitonin gene-related peptide in D rats was prevented by taurine. In summary, the antioxidant taurine reverses neurological and neurovascular deficits in experimental type 2 diabetes.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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