LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response

Sandy MacMillan; Andrew P. Holmes; Mark L. Dallas; Amira D. Mahmoud; Michael J. Shipston; Chris Peers; D. Grahame Hardie; Prem Kumar; A. Mark Evans

doi:10.1038/s42003-022-03583-7

Communications Biology (Jun 2022)

LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response

Sandy MacMillan,
Andrew P. Holmes,
Mark L. Dallas,
Amira D. Mahmoud,
Michael J. Shipston,
Chris Peers,
D. Grahame Hardie,
Prem Kumar,
A. Mark Evans

Affiliations

Sandy MacMillan: Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh
Andrew P. Holmes: School of Biomedical Sciences, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham
Mark L. Dallas: School of Pharmacy, University of Reading
Amira D. Mahmoud: Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh
Michael J. Shipston: Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh
Chris Peers
D. Grahame Hardie: Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee
Prem Kumar: School of Biomedical Sciences, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham
A. Mark Evans: Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh

DOI: https://doi.org/10.1038/s42003-022-03583-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

Read online

Unlike AMPK, Liver kinase B1 (LBK1) is required for carotid body chemosensing and the hypoxic ventilatory response. Moreover, loss of LBK1, but not AMPK, provokes Cheyne-Stokes-like breathing during hypoxia, which is associated with heart failure.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal