Reversible splenial lesion syndrome (RESLES): Two patients as study cases

Siham Nasri, MD; Hajar Abdelaouahhab, MD; Widad Abbou, MD; Imane Guerrouj, MD; Narjisse Aichouni, MD; Imane Kamaoui, MD; Imane Skiker, MD

Radiology Case Reports (Oct 2022)

Reversible splenial lesion syndrome (RESLES): Two patients as study cases

Siham Nasri, MD,
Hajar Abdelaouahhab, MD,
Widad Abbou, MD,
Imane Guerrouj, MD,
Narjisse Aichouni, MD,
Imane Kamaoui, MD,
Imane Skiker, MD

Affiliations

Siham Nasri, MD: Department of Radiology, Mohammed VI University Hospital, Faculty of Medecine, University Mohammed First, Oujda, Morocco; Corresponding author.
Hajar Abdelaouahhab, MD: Department of Radiology, Mohammed VI University Hospital, Faculty of Medecine, University Mohammed First, Oujda, Morocco
Widad Abbou, MD: Department of Radiology, Mohammed VI University Hospital, Faculty of Medecine, University Mohammed First, Oujda, Morocco
Imane Guerrouj, MD: Department of Radiology, Mohammed VI University Hospital, Faculty of Medecine, University Mohammed First, Oujda, Morocco
Narjisse Aichouni, MD: Department of Radiology, Mohammed VI University Hospital, Faculty of Medecine, University Mohammed First, Oujda, Morocco
Imane Kamaoui, MD: Department of Radiology, Mohammed VI University Hospital, Faculty of Medecine, University Mohammed First, Oujda, Morocco; Vascular Anomalies Research Unit, Medical Science Research Laboratory Mohammed VI University hospital, faculty of Medecine, University Mohammed first, Oujda, Morocco
Imane Skiker, MD: Department of Radiology, Mohammed VI University Hospital, Faculty of Medecine, University Mohammed First, Oujda, Morocco

Journal volume & issue: Vol. 17, no. 10
pp. 3635 – 3638

Abstract

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Reversible splenial injury syndrome (RESLES) is a rare clinicoradiological entity that defines a reversible lesion in the splenium of the callosum in magnetic resonance imaging.RESLES may be of infectious iatrogenic or metabolic origin. We report 2 cases of drug induced RESLES in our training.The presence of an isolated lesion of the corpus callosum in a context of polymedication by psychotropic drugs and the regression in less than 4 weeks suggests a toxic origin, in particular medicinal.The pathophysiology of these reversibles lesions of the splenium of callosum is not very clear, most often it is a phenomenon of vasogenic edema that is evoked, the clinical symptoms are very varied and nonspecific, and the prognosis is generally good in the absence of underlying disorder.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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