Nature Communications (Feb 2018)
Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration
- Wei Huang,
- Yuliang Feng,
- Jialiang Liang,
- Hao Yu,
- Cheng Wang,
- Boyu Wang,
- Mingyang Wang,
- Lin Jiang,
- Wei Meng,
- Wenfeng Cai,
- Mario Medvedovic,
- Jenny Chen,
- Christian Paul,
- W. Sean Davidson,
- Sakthivel Sadayappan,
- Peter J. Stambrook,
- Xi-Yong Yu,
- Yigang Wang
Affiliations
- Wei Huang
- Key Laboratory of Molecular Target and Clinical Pharmacology, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University
- Yuliang Feng
- Key Laboratory of Molecular Target and Clinical Pharmacology, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University
- Jialiang Liang
- Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine
- Hao Yu
- Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine
- Cheng Wang
- Department of Molecular Biology, Radboud Institute of Molecular Life Sciences and Faculty of Science, Radboud University
- Boyu Wang
- Samaritan Medical Center
- Mingyang Wang
- College of Engineering and Applied Science, University of Cincinnati
- Lin Jiang
- Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine
- Wei Meng
- Division of Liver Surgery, The Third Affiliated Hospital of Sun Yat-sen University
- Wenfeng Cai
- Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine
- Mario Medvedovic
- Department of Environmental Health, University of Cincinnati College of Medicine
- Jenny Chen
- Department of Environmental Health, University of Cincinnati College of Medicine
- Christian Paul
- Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine
- W. Sean Davidson
- Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine
- Sakthivel Sadayappan
- Division of Cardiovascular Health and Disease, Department of Internal Medicine, Heart, Lung and Vascular Institute, University of Cincinnati College of Medicine
- Peter J. Stambrook
- Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine
- Xi-Yong Yu
- Key Laboratory of Molecular Target and Clinical Pharmacology, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University
- Yigang Wang
- Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-03019-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
During early postnatal development in mammals, cardiomyocytes exit the cell cycle, losing their regenerative capacity. Here the authors show that, following myocardial infarction, loss of microRNA-128 promotes cardiomyocyte proliferation and cardiac regeneration in adult mice partly via enhancing the expression of the chromatin modifier SUZ12.
