Synthesis and Structural Assessment of Methyl 2-(4-Phenyl-5-(Pyridin-2-yl)-4H-1,2,4-Triazol-3-yl)Thioacetate (phpy2NS) and Its Complex with HgCl2

Abstract

Reaction of 2-cyanopyridine with N-phenylthiosemicarbazide afforded the 4-phenyl-5-(pyridin-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione. Methyl 2-((4-phenyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetate (phpy2NS, 1), derived from this 1,2,4-triazole-3-thione, was obtained by reaction with chloroacetic acid followed by an acid-catalyzed esterification of the carboxylic acid with methyl alcohol. Synthesis of a Hg(II) complex, [Hg(phpy2NS)Cl2] (2), has been performed using the ligand (1) and HgCl2. The molecular and supramolecular structures of the ligand and the complex were studied by X-ray diffractometry.

Keywords

• 1,2,4-triazole ligands
• Hg(II) complexes
• crystal engineering
• supramolecular architectures
• hydrogen bond