Nature Communications (Jun 2019)
Aβ-induced vulnerability propagates via the brain’s default mode network
- Tharick A. Pascoal,
- Sulantha Mathotaarachchi,
- Min Su Kang,
- Sara Mohaddes,
- Monica Shin,
- Ah Yeon Park,
- Maxime J. Parent,
- Andrea L. Benedet,
- Mira Chamoun,
- Joseph Therriault,
- Heungsun Hwang,
- A. Claudio Cuello,
- Bratislav Misic,
- Jean-Paul Soucy,
- John A. D. Aston,
- Serge Gauthier,
- Pedro Rosa-Neto
Affiliations
- Tharick A. Pascoal
- Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging
- Sulantha Mathotaarachchi
- Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging
- Min Su Kang
- Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging
- Sara Mohaddes
- Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging
- Monica Shin
- Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging
- Ah Yeon Park
- Statistical Laboratory, University of Cambridge
- Maxime J. Parent
- Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging
- Andrea L. Benedet
- Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging
- Mira Chamoun
- Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging
- Joseph Therriault
- Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging
- Heungsun Hwang
- Department of Psychology, McGill University
- A. Claudio Cuello
- Department of Pharmacology and Therapeutics, McGill University
- Bratislav Misic
- Montreal Neurological Institute
- Jean-Paul Soucy
- Montreal Neurological Institute
- John A. D. Aston
- Statistical Laboratory, University of Cambridge
- Serge Gauthier
- Alzheimer’s Disease Research Unit, The McGill University Research Centre for Studies in Aging
- Pedro Rosa-Neto
- Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging
- DOI
- https://doi.org/10.1038/s41467-019-10217-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Amyloid-β (Aβ) deposition occurs in Alzheimer's disease but its relation to disease features such as local brain hypometabolism or cognitive decline is unclear. Here, the authors show that Aβ aggregation in the brain’s default mode network leads to hypometabolism in distant but functionally connected areas.
