Frontiers in Neuroscience (Oct 2023)
Exploring the brain epitranscriptome: perspectives from the NSAS summit
- Sung-Min Lee,
- Sung-Min Lee,
- Bonsang Koo,
- Bonsang Koo,
- Clément Carré,
- André Fischer,
- Chuan He,
- Chuan He,
- Ajeet Kumar,
- Ajeet Kumar,
- Kathy Liu,
- Kate D. Meyer,
- Kate D. Meyer,
- Guo-li Ming,
- Guo-li Ming,
- Guo-li Ming,
- Guo-li Ming,
- Junmin Peng,
- Junmin Peng,
- Jean-Yves Roignant,
- Jean-Yves Roignant,
- Erik Storkebaum,
- Shuying Sun,
- Davide De Pietri Tonelli,
- Yinsheng Wang,
- Yi-Lan Weng,
- Luigi Pulvirenti,
- Yanhong Shi,
- Ki-Jun Yoon,
- Ki-Jun Yoon,
- Hongjun Song,
- Hongjun Song,
- Hongjun Song,
- Hongjun Song
Affiliations
- Sung-Min Lee
- Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
- Sung-Min Lee
- KAIST Stem Cell Center, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
- Bonsang Koo
- Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
- Bonsang Koo
- KAIST Stem Cell Center, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
- Clément Carré
- Transgenerational Epigenetics & Small RNA Biology, Centre National de la Recherche Scientifique, Laboratoire de Biologie du Développement - Institut de Biologie Paris Seine, Sorbonne Université, Paris, France
- André Fischer
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany
- Chuan He
- Department of Chemistry, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, United States
- Chuan He
- Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, United States
- Ajeet Kumar
- Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
- Ajeet Kumar
- KAIST Stem Cell Center, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
- Kathy Liu
- Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, United States
- Kate D. Meyer
- Department of Biochemistry, Duke University School of Medicine, Durham, NC, United States
- Kate D. Meyer
- Department of Neurobiology, Duke University School of Medicine, Durham, NC, United States
- Guo-li Ming
- 0Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
- Guo-li Ming
- 1Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, United States
- Guo-li Ming
- 2Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
- Guo-li Ming
- 3Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
- Junmin Peng
- 4Department of Structural Biology, St. Jude Children's Research Hospital, Danny Thomas Place, Memphis, TN, United States
- Junmin Peng
- 5Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Danny Thomas Place, Memphis, TN, United States
- Jean-Yves Roignant
- 6Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
- Jean-Yves Roignant
- 7Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University Mainz, Mainz, Staudingerweg, Germany
- Erik Storkebaum
- 8Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands
- Shuying Sun
- 9Department of Physiology and Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States
- Davide De Pietri Tonelli
- 0Neurobiology of miRNA, Fondazione Istituto Italiano di Tecnologia (IIT), Genova, Italy
- Yinsheng Wang
- 1Department of Chemistry, University of California, Riverside, CA, United States
- Yi-Lan Weng
- 2Department of Neurosurgery, Houston Methodist Neurological Institute, Houston, TX, United States
- Luigi Pulvirenti
- 3Neuroscience School of Advanced Studies, London, United Kingdom
- Yanhong Shi
- 4Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, Duarte, CA, United States
- Ki-Jun Yoon
- Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
- Ki-Jun Yoon
- KAIST Stem Cell Center, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
- Hongjun Song
- 0Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
- Hongjun Song
- 1Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, United States
- Hongjun Song
- 2Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
- Hongjun Song
- 5The Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
- DOI
- https://doi.org/10.3389/fnins.2023.1291446
- Journal volume & issue
-
Vol. 17
Abstract
Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neurodegeneration, and brain tumorigenesis, leading to the emergence of a new field termed neuroepitranscriptomics. Deficiency in machineries modulating RNA modifications has been implicated in a range of brain disorders from microcephaly, intellectual disability, seizures, and psychiatric disorders to brain cancers such as glioblastoma. The inaugural NSAS Challenge Workshop on Brain Epitranscriptomics hosted in Crans-Montana, Switzerland in 2023 assembled a group of experts from the field, to discuss the current state of the field and provide novel translational perspectives. A summary of the discussions at the workshop is presented here to simulate broader engagement from the general neuroscience field.
Keywords
- RNA modifications
- epitranscriptome
- neuroepitranscriptomics
- neurodevelopment
- neurogenesis
- glioblastoma
