Nature Communications (May 2019)

Nanopore blockade sensors for ultrasensitive detection of proteins in complex biological samples

  • Kyloon Chuah,
  • Yanfang Wu,
  • S. R. C. Vivekchand,
  • Katharina Gaus,
  • Peter J. Reece,
  • Adam P. Micolich,
  • J. Justin Gooding

DOI
https://doi.org/10.1038/s41467-019-10147-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

Read online

Nanopore sensors have long analysis times when analytes are at low concentration and non-specific signals in complex media. Here the authors use antibody-modified magnetic nanoparticles to detect prostate-specific antigen at sub-femtomolar concentrations in blood.