Negative symptoms of schizophrenia in patients with acute and transient psychotic disorders

Abstract

Introduction The ICD-10 acute and transient psychotic disorders (ATPD, F23) without symptoms of schizophrenia are considered predominantly reactive psychotic disorders or affective pathology. However, negative symptoms of schizophrenia may be revealed in some of these cases after the psychotic reduction. Objectives To investigate the association between the developmental characteristics of psychosis and the negative symptoms detection after the psychotic reduction of ATPD without symptoms of schizophrenia. Methods 68 adult inpatients with ATPD without symptoms of schizophrenia (F23.0) were examined. Negative symptoms were assessed with the PANSS negative symptom subscale (PANSS-NSS). The sample was divided into two groups: with PANSS-NSS score>14 (n=12) and with PANSS-NSS score≤14 (n=56), respectively. Clinical-psychopathological, psychometric and statistical methods were applied. Results The results of the study are presented in Table 1. Table 1. The ATPD developmental features Features The 1 st group (n=12) The 2 nd group (n=56) Pearson’s contingency coefficient (C) Males 7 (58,3%) 37 (66,1%) 0.062 Females 5 (41,7%) 19 (33,9%) 0.062 Mean age of psychotic onset, years (М±m) 24,9±10,5 30,8±10,2 - Family history of schizophrenia* 4 (33,3%) 1 (1,8%) 0.418 Poor premorbid social adaptation* 5 (41,7%) 0 0.520 Prodromal functional decline* 9 (75,0%) 4 (7,1%) 0.550 Prodromal non-psychotic symptoms 9 (75,0%) 30 (53,6%) 0.163 Associated acute stress 4 (33,3%) 27 (48,2%) 0.113 *p<0,001 Conclusions The probability of negative symptoms detection in ATPD without symptoms of schizophrenia is relatively strongly associated with the family history of schizophrenia, poor premorbid social adaptation and functional decline prior to the psychotic onset. Disclosure No significant relationships.

Keywords

• negative symptoms
• schizophrénia
• Acute and transient psychotic disorder