APEX2 Proximity Proteomics Resolves Flagellum Subdomains and Identifies Flagellum Tip-Specific Proteins in Trypanosoma brucei

mSphere (Feb 2021)

Affiliations

Daniel E. Vélez-Ramírez: ORCiD; Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
Michelle M. Shimogawa: Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
Sunayan S. Ray: ORCiD; Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
Andrew Lopez: Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
Shima Rayatpisheh: Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, USA
Gerasimos Langousis: Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
Marcus Gallagher-Jones: Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Los Angeles, California, USA
Samuel Dean: Warwick Medical School, University of Warwick, Coventry, United Kingdom
James A. Wohlschlegel: Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, USA
Kent L. Hill: ORCiD; Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA

Abstract

Sleeping sickness is a neglected tropical disease caused by the protozoan parasite Trypanosoma bruceiT. brucei