Nature Communications (Jan 2022)

RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

  • Germán Belenguer,
  • Gianmarco Mastrogiovanni,
  • Clare Pacini,
  • Zoe Hall,
  • Anna M. Dowbaj,
  • Robert Arnes-Benito,
  • Aleksandra Sljukic,
  • Nicole Prior,
  • Sofia Kakava,
  • Charles R. Bradshaw,
  • Susan Davies,
  • Michele Vacca,
  • Kourosh Saeb-Parsy,
  • Bon-Kyoung Koo,
  • Meritxell Huch

DOI
https://doi.org/10.1038/s41467-021-27923-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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The E3 ubiquitin ligases RNF43/ZNRF3 are often mutated in cancer but their precise contribution to liver disease is unknown. Here, the authors show that RNF43/ZNRF3 alterations predispose to liver cancer by controlling the differentiation and lipid metabolic state of hepatocytes.