Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors

Roman Rohac; Jason C. Crack; Eve de Rosny; Océane Gigarel; Nick E. Le Brun; Juan C. Fontecilla-Camps; Anne Volbeda

doi:10.1038/s42003-022-03745-7

Communications Biology (Jul 2022)

Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors

Roman Rohac,
Jason C. Crack,
Eve de Rosny,
Océane Gigarel,
Nick E. Le Brun,
Juan C. Fontecilla-Camps,
Anne Volbeda

Affiliations

Roman Rohac: Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, Metalloproteins Unit
Jason C. Crack: Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich Research Park
Eve de Rosny: Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, Metalloproteins Unit
Océane Gigarel: Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, Metalloproteins Unit
Nick E. Le Brun: Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich Research Park
Juan C. Fontecilla-Camps: Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, Metalloproteins Unit
Anne Volbeda: Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, Metalloproteins Unit

DOI: https://doi.org/10.1038/s42003-022-03745-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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The crystal structure of the iron-sulfur protein NsrR from Streptomyces coelicolor bound to a gene operator fragment is reported and compared with other structures, giving insight into the structural determinants of DNA recognition by the NO sensor.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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