Diabetes, Metabolic Syndrome and Obesity (Apr 2020)

Evaluation of Hypoglycemic Therapy Through Physical Exercise in n5STZ-Induced Diabetes Rats

  • Ribeiro JKC,
  • Nascimento TV,
  • Agostinho AG,
  • Freitas RM,
  • Santos LHP,
  • Machado LMQ,
  • Leal-Cardoso JH,
  • Moreira-Gomes MD,
  • Ceccatto VM

Journal volume & issue
Vol. Volume 13
pp. 991 – 1004

Abstract

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JKC Ribeiro, TV Nascimento, AG Agostinho, RM Freitas, LHP Santos, LMQ Machado, JH Leal-Cardoso, MD Moreira-Gomes, VM Ceccatto Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, CE, BrazilCorrespondence: VM CeccattoInstituto de Ciências Biomédicas, Universidade Estadual do Ceará, Av Paranjana, 1700, Fortaleza, Ceará 60740-000, BrazilTel +55 85 3101 9814Fax +55 85 3101 9796Email [email protected]: Diabetes mellitus is a syndrome with multiple etiologies involving insulin, in which there is a lack of production and/or loss of sensitivity to this hormone resulting in insulin resistance. Treatment and control of this disease requires changes in diet, use of medication, and lifestyle, such as physical activity. These modifications may compromise quality-of-life if there is no proper guidance for the treatment or alert to possible complications caused by the disease.Methods: This study aimed to evaluate biochemical and hematological parameters, and to assess brain derived neurotrophic factor levels in diabetic Wistar rats submitted to chronic physical exercise.Results: The results demonstrated an increase in plasma concentration of brain-derived neurotrophic factor (BDNF) in association with hyperglycemia reduction in diabetic animals.Discussion: The results obtained suggest that there is a regulation of glucose homeostasis between peripheral tissues and the central nervous system. Exercise-induced BDNF also improved levels of glycemia, body weight, and dyslipidemia. In hematological evaluation, BDNF increase was positively correlated with an improvement in leukocyte parameters. Electrophoresis analyses demonstrated a reduction in levels of pro-inflammatory proteins, lipoprotein fractions, and albumin preservation in diabetic animals trained with elevated concentration of plasma BDNF.Conclusion: In conclusion, this study demonstrated that chronic exercise was able to elevate BDNF levels in plasma, which resulted directly in positive hypoglycemic activity in diabetic animals and a reduction of the metabolic syndrome associated with diabetes mellitus.Keywords: diabetes mellitus, dyslipidemia, exercise, n5-STZ, BDNF

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