The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

Alon Herschhorn; Christopher Gu; Francesca Moraca; Xiaochu Ma; Mark Farrell; Amos B. Smith; Marie Pancera; Peter D. Kwong; Arne Schön; Ernesto Freire; Cameron Abrams; Scott C. Blanchard; Walther Mothes; Joseph G. Sodroski

doi:10.1038/s41467-017-01119-w

Nature Communications (Oct 2017)

The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

Alon Herschhorn,
Christopher Gu,
Francesca Moraca,
Xiaochu Ma,
Mark Farrell,
Amos B. Smith,
Marie Pancera,
Peter D. Kwong,
Arne Schön,
Ernesto Freire,
Cameron Abrams,
Scott C. Blanchard,
Walther Mothes,
Joseph G. Sodroski

Affiliations

Alon Herschhorn: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute
Christopher Gu: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute
Francesca Moraca: Department of Chemical and Biological Engineering, Drexel University
Xiaochu Ma: Department of Microbial Pathogenesis, Yale University School of Medicine
Mark Farrell: Department of Chemistry, University of Pennsylvania
Amos B. Smith: Department of Chemistry, University of Pennsylvania
Marie Pancera: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Peter D. Kwong: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Arne Schön: Department of Biology, Johns Hopkins University
Ernesto Freire: Department of Biology, Johns Hopkins University
Cameron Abrams: Department of Chemical and Biological Engineering, Drexel University
Scott C. Blanchard: Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University
Walther Mothes: Department of Microbial Pathogenesis, Yale University School of Medicine
Joseph G. Sodroski: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute

DOI: https://doi.org/10.1038/s41467-017-01119-w
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Binding of viral envelope glycoproteins (Env) to the host cell CD4 receptor mediates HIV-1 entry. Here, the authors develop compounds that inhibit the CD4-induced conformational changes in Env and show that the gp120 β20-β21 element is a key regulator for Env transitions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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