Nature Communications (Apr 2021)
Systems serology detects functionally distinct coronavirus antibody features in children and elderly
- Kevin J. Selva,
- Carolien E. van de Sandt,
- Melissa M. Lemke,
- Christina Y. Lee,
- Suzanne K. Shoffner,
- Brendon Y. Chua,
- Samantha K. Davis,
- Thi H. O. Nguyen,
- Louise C. Rowntree,
- Luca Hensen,
- Marios Koutsakos,
- Chinn Yi Wong,
- Francesca Mordant,
- David C. Jackson,
- Katie L. Flanagan,
- Jane Crowe,
- Shidan Tosif,
- Melanie R. Neeland,
- Philip Sutton,
- Paul V. Licciardi,
- Nigel W. Crawford,
- Allen C. Cheng,
- Denise L. Doolan,
- Fatima Amanat,
- Florian Krammer,
- Keith Chappell,
- Naphak Modhiran,
- Daniel Watterson,
- Paul Young,
- Wen Shi Lee,
- Bruce D. Wines,
- P. Mark Hogarth,
- Robyn Esterbauer,
- Hannah G. Kelly,
- Hyon-Xhi Tan,
- Jennifer A. Juno,
- Adam K. Wheatley,
- Stephen J. Kent,
- Kelly B. Arnold,
- Katherine Kedzierska,
- Amy W. Chung
Affiliations
- Kevin J. Selva
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Carolien E. van de Sandt
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Melissa M. Lemke
- Department of Biomedical Engineering, University of Michigan
- Christina Y. Lee
- Department of Biomedical Engineering, University of Michigan
- Suzanne K. Shoffner
- Department of Biomedical Engineering, University of Michigan
- Brendon Y. Chua
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Samantha K. Davis
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Thi H. O. Nguyen
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Louise C. Rowntree
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Luca Hensen
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Marios Koutsakos
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Chinn Yi Wong
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Francesca Mordant
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- David C. Jackson
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Katie L. Flanagan
- Department of Infectious Diseases and Tasmanian Vaccine Trial Centre, Launceston General Hospital
- Jane Crowe
- Deepdene Surgery
- Shidan Tosif
- Infection and Immunity, Murdoch Children’s Research Institute
- Melanie R. Neeland
- Infection and Immunity, Murdoch Children’s Research Institute
- Philip Sutton
- Infection and Immunity, Murdoch Children’s Research Institute
- Paul V. Licciardi
- Infection and Immunity, Murdoch Children’s Research Institute
- Nigel W. Crawford
- Infection and Immunity, Murdoch Children’s Research Institute
- Allen C. Cheng
- School of Public Health and Preventive Medicine, Monash University
- Denise L. Doolan
- Centre for Molecular Therapeutics, Australian Institute of Tropical Health & Medicine, James Cook University
- Fatima Amanat
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Florian Krammer
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Keith Chappell
- School of Chemistry and Molecular Bioscience, University of Queensland
- Naphak Modhiran
- School of Chemistry and Molecular Bioscience, University of Queensland
- Daniel Watterson
- School of Chemistry and Molecular Bioscience, University of Queensland
- Paul Young
- School of Chemistry and Molecular Bioscience, University of Queensland
- Wen Shi Lee
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Bruce D. Wines
- Immune Therapies Group, Burnet Institute
- P. Mark Hogarth
- Immune Therapies Group, Burnet Institute
- Robyn Esterbauer
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Hannah G. Kelly
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Hyon-Xhi Tan
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Jennifer A. Juno
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Adam K. Wheatley
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Stephen J. Kent
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Kelly B. Arnold
- Department of Biomedical Engineering, University of Michigan
- Katherine Kedzierska
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Amy W. Chung
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- DOI
- https://doi.org/10.1038/s41467-021-22236-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Antibody responses to SARS-CoV-2 are critical in the immune response to infection, but the potential cross-reactivity to other human corona viruses is poorly appreciated. Here the authors apply a systems based approach to characterise the antibody response in pre-pandemic cohorts and assess heterotypic reactivity to SARS-CoV-2.
