Tracing tumorigenesis in a solid tumor model at single-cell resolution

Samantha D. Praktiknjo; Benedikt Obermayer; Qionghua Zhu; Liang Fang; Haiyue Liu; Hazel Quinn; Marlon Stoeckius; Christine Kocks; Walter Birchmeier; Nikolaus Rajewsky

doi:10.1038/s41467-020-14777-0

Nature Communications (Feb 2020)

Tracing tumorigenesis in a solid tumor model at single-cell resolution

Samantha D. Praktiknjo,
Benedikt Obermayer,
Qionghua Zhu,
Liang Fang,
Haiyue Liu,
Hazel Quinn,
Marlon Stoeckius,
Christine Kocks,
Walter Birchmeier,
Nikolaus Rajewsky

Affiliations

Samantha D. Praktiknjo: Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Benedikt Obermayer: Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Qionghua Zhu: Signal Transduction in Development and Cancer, Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Liang Fang: Signal Transduction in Development and Cancer, Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Haiyue Liu: Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Hazel Quinn: Signal Transduction in Development and Cancer, Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Marlon Stoeckius: New York Genome Center
Christine Kocks: Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Walter Birchmeier: Signal Transduction in Development and Cancer, Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Nikolaus Rajewsky: Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association

DOI: https://doi.org/10.1038/s41467-020-14777-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

Read online

Understanding tumour development at a granular level is a challenge in solid tumours. Here, the authors provide a cell atlas across tumour development in a genetic model of salivary gland squamous cell carcinoma using single-cell transcriptome and epitope profiling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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