Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes

Abstract

LACC1 genetic variants are associated with Crohn's disease, leprosy and arthritis. Here the authors show that LACC1 is needed for optimal innate receptor-induced signalling, mitochondrial ROS production and microbial clearance, effects that are reduced by a Crohn's disease-risk variant in LACC1.