INVESTIGATION OF CALCIUM-PHOSPHORIC EXCHANGE IN WOMEN WITH THE MENOPAUSE STATE SUFFERING FROM OSTEOARTHROSIS AND CONCOMITANT OSTEOPENIC SYNDROME

Abstract

Objective: To study changes in calcium-phosphorus metabolism, bone metabolism and mineral bone density in osteoarthritis with the concomitant osteopenic syndrome in women with the menopause state. Methods: We examined 40 women in the state of menopause (50-60 years), patients with osteoarthrosis of the hip joints, with a duration of disease of 3-5 and more years (the main group), and 20 healthy women of the same age (control group). Results: An increase (p<0.05) of the serum level of the C-terminal telopeptide of type I collagen, a marker of bone resorption, a predominance speed of bone resorption rate over bone formation, while no significant deviations in the level of phosphatemia and calcemia were observed with a tendency to decrease activity of alkaline phosphatase and the level of osteocalcin – markers of bone formation in serum. In addition, osteopenia has been noted in various parts of the skeleton: in the spine with a predominantly trabecular type of bone structure. Conclusion: The revealed multiple correlation relationships of the main characteristic indicators of osteoarthrosis with markers of bone resorption once again testify the comorbidity of osteoarthritis with osteoporosis.

Keywords

• osteoarthritis
• osteopenic syndrome
• calcium-phosphorus metabolism
• bone metabolism
• menopause.