Emerging Infectious Diseases (May 2024)

SARS-CoV-2 IgG Levels as Predictors of XBB Variant Neutralization, Israel, 2022­ and 2023

  • Yaniv Lustig,
  • Michal Canetti,
  • Victoria Indenbaum,
  • Yovel Peretz,
  • Yael Weiss-Ottolenghi,
  • Ili Margalit,
  • Keren Asraf,
  • Tal Levin,
  • Neta Zuckerman,
  • Enosh Tomer,
  • Michal Mandelboim,
  • Ram Doolman,
  • Noam Barda,
  • Gili Regev-Yochay

DOI
https://doi.org/10.3201/eid3005.231739
Journal volume & issue
Vol. 30, no. 5
pp. 1050 – 1052

Abstract

Read online

Although a vaccine against SARS-CoV-2 Omicron-XBB.1.5 variant is available worldwide and recent infection is protective, the lack of recorded infection data highlights the need to assess variant-specific antibody neutralization levels. We analyzed IgG levels against receptor-binding domain–specific SARS-CoV-2 ancestral strain as a correlate for high neutralizing titers against XBB variants.

Keywords