Role of compositional disorders in phospholipids in the pathogenesis of cytomegalovirus infection in the gestation period

Abstract

We studied the composition of phospholipids and phospholipase A2 in 96 pregnant women c cytomegalovirus infection (titer of IgG antibodies to cytomegalovirus 1 : 1600). It was found that the aggravation of CMV infection in pregnant women is accompanied with membrane-destructive phenomena, which are based on the activation of phospholipase A2 and the modification of the phospholipid matrix exhibits decrease of phosphatidylethanolamine (I trimester - by 24%, II trimester - by 16 %, III trimester - by 9 % (p < 0,001)); phosphatidylcholine (I trimester - by 14 %, II trimester - by 16 %, III trimester - 23 % (p < 0,001)); phosphatidylserine (I trimester - by 46 % (p < 0,001), II trimester - by 33 % (p < 0,01), III trimester - by 101 % (p < 0,001)). Increasing the concentration of sphingomyelin (I trimester - by 16 %, II and III trimesters - by 9 %; p < 0,001), lysophosphatidylcholine (I trimester - by 71 %, II trimester - 59 %, III trimester - by 51 % (p < 0,001)) compared with healthy women. Identified changes may be the significant factor in violation of the deformability of cells, red blood cell hemolysis, increased microviscosity blood, and therefore is the cause of fetal hypoxia.

Keywords

• phospholipids
• phospholipase a₂
• pregnancy
• cytomegalovirus infection