Nature Communications (Nov 2019)

A Bayesian mixture model for the analysis of allelic expression in single cells

  • Kwangbom Choi,
  • Narayanan Raghupathy,
  • Gary A. Churchill

DOI
https://doi.org/10.1038/s41467-019-13099-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

Allele-specific expression at single-cell resolution can reveal stochastic and dynamic features of gene expression in greater detail. The authors propose scBASE, a soft zero-and-one inflated model that improves estimation of cellular allelic proportions by pooling information across cells.