Haematologica (Jan 2007)

Transient hypoxia and downregulation of circulating prohepcidin concentrations in healthy young men

  • Christian Benedict,
  • Andrew J. Ghio,
  • Hartmut Gehring,
  • Bernd Schultes,
  • Achim Peters,
  • Kerstin M. Oltmanns

DOI
https://doi.org/10.3324/haematol.10637
Journal volume & issue
Vol. 92, no. 1

Abstract

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To determine the impact of acute hypoxia on prohepcidin concentrations in humans, we measured concentrations of this peptide in serum collected during and after a transient period (30 min) of hypoxia and during normoxia. Prohepcidin concentrations were significantly lower 150 min after the end of hypoxia than after normoxia (p=0.028).