Nature Communications (Mar 2019)

Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents

  • Ting Zou,
  • Lixiong Gao,
  • Yuxiao Zeng,
  • Qiyou Li,
  • Yijian Li,
  • Siyu Chen,
  • Xisu Hu,
  • Xi Chen,
  • Caiyun Fu,
  • Haiwei Xu,
  • Zheng Qin Yin

DOI
https://doi.org/10.1038/s41467-019-08961-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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Stem cell transplantation to treat retinal degeneration could be limited by the degenerative microenvironment. Here, the authors show that C-Kit+/SSEA4– progenitor cells enriched from human embryonic stem cell derived retinal organoids protect retinal structure, suppress microglial activation, gliosis and inflammation.