Nature Communications (Jan 2022)
Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood
- Xiao-Hui Wang,
- Bo-Wen Gao,
- Yu Nakashima,
- Takahiro Mori,
- Zhong-Xiu Zhang,
- Takeshi Kodama,
- Yuan-E Lee,
- Ze-Kun Zhang,
- Chin-Piow Wong,
- Qian-Qian Liu,
- Bo-Wen Qi,
- Juan Wang,
- Jun Li,
- Xiao Liu,
- Ikuro Abe,
- Hiroyuki Morita,
- Peng-Fei Tu,
- She-Po Shi
Affiliations
- Xiao-Hui Wang
- Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine
- Bo-Wen Gao
- Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine
- Yu Nakashima
- Institute of Natural Medicine, University of Toyama
- Takahiro Mori
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Zhong-Xiu Zhang
- Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine
- Takeshi Kodama
- Institute of Natural Medicine, University of Toyama
- Yuan-E Lee
- Institute of Natural Medicine, University of Toyama
- Ze-Kun Zhang
- Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine
- Chin-Piow Wong
- Institute of Natural Medicine, University of Toyama
- Qian-Qian Liu
- Institute of Natural Medicine, University of Toyama
- Bo-Wen Qi
- Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine
- Juan Wang
- Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine
- Jun Li
- Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine
- Xiao Liu
- Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine
- Ikuro Abe
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Hiroyuki Morita
- Institute of Natural Medicine, University of Toyama
- Peng-Fei Tu
- Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine
- She-Po Shi
- Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine
- DOI
- https://doi.org/10.1038/s41467-022-27971-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
2-(2-Phenylethyl)chromones (PECs) contribute to the distinctive fragrance of agarwood. Here the authors identify a diarylpentanoid-producing polyketide synthase from Aquilaria sinensis and show how it catalyzes PEC formation.
