Проблемы особо опасных инфекций (Mar 2013)

Results of Modeling Experiments in Designing Immuno-Enzyme Test-System for the Detection of Antibodies to <I>Yersinia pestis</I> F1 (ELISA-Ab-F1 <I>Yersinia pestis</I>)

  • Z. L. Devdariani,
  • N. E. Tereshkina,
  • T. M. Taranenko,
  • M. N. Kireev,
  • I. V. Terekhova,
  • G. V. Grigor’Eva,
  • M. N. Islyaeva,
  • N. M. Ermakov,
  • N. A. Vinogradova,
  • A. N. Malakhaeva

DOI
https://doi.org/10.21055/0370-1069-2013-1-74-77
Journal volume & issue
Vol. 0, no. 1
pp. 74 – 77

Abstract

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Designed is immuno-enzyme test-system for the detection of antibodies to Yersinia pestis capsular antigen F1 – “ELISA-Ab-F1 Yersinia pestis”. On the model of laboratory mice it is demonstrated that this test-system is highly specific, its diagnostic titer being 1/320.Diagnostic value of the test-system is 83.3–88.9 % as revealed through investigations of sera and blood suspension samples, swabs of thoracic organs of animals, inoculated with live plague vaccine, strains of plague microbe, containing and deprived of pFra, as well as with heterologous bacteria.

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