BMC Genetics (Aug 2007)

The PhenoGen Informatics website: tools for analyses of complex traits

  • Jones Kendra,
  • Ellington Eric,
  • Ellington Allison,
  • Soriano Brian,
  • Leach Sonia,
  • Dolbey Andrew,
  • McGoldrick Daniel,
  • Gaydos Jeanette,
  • Kechris Katherina,
  • Lapadat Razvan,
  • Saba Laura,
  • Phang Tzu L,
  • Hornbaker Cheryl,
  • Bhave Sanjiv V,
  • Mangion Jonathan,
  • Belknap John K,
  • Williams Robert W,
  • Hunter Lawrence E,
  • Hoffman Paula L,
  • Tabakoff Boris

DOI
https://doi.org/10.1186/1471-2156-8-59
Journal volume & issue
Vol. 8, no. 1
p. 59

Abstract

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Abstract Background With the advent of "omics" (e.g. genomics, transcriptomics, proteomics and phenomics), studies can produce enormous amounts of data. Managing this diverse data and integrating with other biological data are major challenges for the bioinformatics community. Comprehensive new tools are needed to store, integrate and analyze the data efficiently. Description The PhenoGen Informatics website http://phenogen.uchsc.edu is a comprehensive toolbox for storing, analyzing and integrating microarray data and related genotype and phenotype data. The site is particularly suited for combining QTL and microarray data to search for "candidate" genes contributing to complex traits. In addition, the site allows, if desired by the investigators, sharing of the data. Investigators can conduct "in-silico" microarray experiments using their own and/or "shared" data. Conclusion The PhenoGen website provides access to tools that can be used for high-throughput data storage, analyses and interpretation of the results. Some of the advantages of the architecture of the website are that, in the future, the present set of tools can be adapted for the analyses of any type of high-throughput "omics" data, and that access to new tools, available in the public domain or developed at PhenoGen, can be easily provided.