Design, synthesis and biological activity against estrogen receptor-dependent breast cancer of furo[1]benzofuran derivatives

Abstract

The docking study on a series of furo[1]benzofuran derivatives with ERα has been demonstrated. The synthesis and characterization of a series of furo[1]benzofuran derivatives were described. All the target compounds were conducted to in vitro for the inhibitory activities against human breast cancer strains T-47D, MCF-7 and toxicity against human liver normal cell strains HL7702 via MTT assay. Most of the target compounds possessed anti-estrogen receptor-dependent breast cancer activities with weak toxicity to healthy cell strains. The preliminary structure–activity relationships were discussed.

Keywords

• Estrogen receptor
• Breast cancer
• Inhibitors
• Synthesis
• Heterocycles
• Docking