A megaplasmid family driving dissemination of multidrug resistance in Pseudomonas

Adrian Cazares; Matthew P. Moore; James P.  J. Hall; Laura L. Wright; Macauley Grimes; Jean-Guillaume Emond-Rhéault; Pisut Pongchaikul; Pitak Santanirand; Roger C. Levesque; Joanne L. Fothergill; Craig Winstanley

doi:10.1038/s41467-020-15081-7

Nature Communications (Mar 2020)

A megaplasmid family driving dissemination of multidrug resistance in Pseudomonas

Adrian Cazares,
Matthew P. Moore,
James P. J. Hall,
Laura L. Wright,
Macauley Grimes,
Jean-Guillaume Emond-Rhéault,
Pisut Pongchaikul,
Pitak Santanirand,
Roger C. Levesque,
Joanne L. Fothergill,
Craig Winstanley

Affiliations

Adrian Cazares: Institute of Infection and Global Health, University of Liverpool
Matthew P. Moore: Institute of Infection and Global Health, University of Liverpool
James P. J. Hall: Department of Evolution, Ecology and Behaviour, University of Liverpool
Laura L. Wright: Institute of Infection and Global Health, University of Liverpool
Macauley Grimes: Institute of Infection and Global Health, University of Liverpool
Jean-Guillaume Emond-Rhéault: Institute for Integrative and Systems Biology (IBIS), University Laval
Pisut Pongchaikul: Ramathibodi Hospital, Mahidol University
Pitak Santanirand: Ramathibodi Hospital, Mahidol University
Roger C. Levesque: Institute for Integrative and Systems Biology (IBIS), University Laval
Joanne L. Fothergill: Institute of Infection and Global Health, University of Liverpool
Craig Winstanley: Institute of Infection and Global Health, University of Liverpool

DOI: https://doi.org/10.1038/s41467-020-15081-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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The emergence of multidrug resistance (MDR) in bacteria represents a global threat to human health. Here, Cazares et al. identify a family of MDR megaplasmids carrying large arrays of antibiotic resistance genes in Pseudomonas strains from various sources, including P. aeruginosa clinical isolates.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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