Mechanism and kinetics of uric acid adsorption on nanosized hydroxyapatite coating

Abstract

Uric acid (UA) produced from purine metabolism is rather harmful to human health when its concentration is high. To better understand the application of hydroxyapatite (HAP) as an adsorbent for UA removal, quartz crystal microbalance (QCM) technique was employed to in situ investigate the adsorption behavior of UA on nanosized HAP coatings. This work was mainly focused on the mechanism and kinetics of UA adsorption. The obtained results showed that nanosized HAP coatings produced physical adsorption for UA, and the driving force of UA adsorption on HAP coatings was electrostatic interaction. The adsorption kinetic parameter estimated from the in situ frequency measurement was about 3.08 × 106 L/mol. The obtained information suggests that QCM measurement provides a useful method for monitoring the interaction between HAP and UA. Keywords: Uric acid, Nanosized hydroxyapatite coating, Mechanism, Kinetics, Quartz crystal microbalance